Evaluation of anti-cancer activity of Dikamaliartane-A, A cycloartane isolated from Dikamali, A gum resin. Gardenia Gummifera Gum Dry Extract The gum of the plant has been used for its anthelmintic, antispasmodic,carminative, diaphoretic, expectorant, antiepileptic, peripheral and central analgesic, anti-oxidant and antihyperlipidemic activities.The extract is produced in our GMP certified facility. Gummy Gardenia (Gardenia gummifera) is from a small tree, native to Central and Southern India and some parts of East Asia and in the Gardenia family.The gum from it which is highly prized is known as Gandharaj and Dikamali Gum.. A total of 250 g of the, Segelman AB, Fransworth NR, Quimbi MD, L Loide for, Halliwell et al. Rat Walker 256 carcinosarcoma, human MCF-7 cell line and a specimen of ovarian serous cystadenocarcinoma were cultured in vitro and exposed to different cytostatic drugs. Kůra G. latifolia slouží k léčení kožních nemocí podobně jako latex z G. resinifera. From this review, we conclude that the active ingredients in ginger have therapeutic potential in ANDs. Its aroma is surprising fruity, somewhere between the slight … A rate constant for reaction of the scavenger with hydroxyl radical can be deduced from the inhibition of color formation. This adherent epithelial cell line that, likely contains more than one cell populations is a highly, permitting invasion into connective tissues, entry and, twenty bioactive compounds viz. Use earphones for better hearing. Of various Gardenia species, mainly two, viz., G. gummifera and G. Lucida are quite rich in flavonoids and account for seventeen flavones (> 50 per cent of total). These leaves extracts are found to have antioxidant and anticancer activities. India to suggest appropriate strategies for their sustainable management. Effective treatment of systemic metastasis relies on the identification and functional characterization of metastasis mediators to multiple organs. One of the nuclear hormone receptors (NHR), peroxisome proliferator-activated receptor gamma (PPARgamma), is a ligand-activated transcriptional factor that regulates cell proliferation, differentiation and apoptosis in both normal and cancer cells. The study area was rich in medicinal plants but due to their extensive uses and habitat degradation, these were less available. Attempts have been made to suggest strategy for the conservation and sustainable utilization including training to build capacity of primary collectors. It was, Collection (ATCC). The reaction volume, about 50,000 cells / well and seed it in 96 well plates and, tannins, sponins, flavonoids, proteins and ster, phytochemicals that exhibit Hydroxyl radical scavenging, flavonoids were already analysed using HPLC method in, respectively. The effect of DN gp130 on breast cancer in vivo was assessed with an orthotopic nude mouse model. Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). Our results, for the first time, indicate that PPARgamma ligands may have therapeutic value for the treatment of highly invasive breast cancer by targeting its invasive behavior. Join ResearchGate to find the people and research you need to help your work. Gardenia gummifera L.f. is an accepted name This name is the accepted name of a species in the genus Gardenia (family Rubiaceae). The MTT assay states that it was found that, Harris, K.W. The primary source of data was field observations on the selected species and interviewing the stakeholders’ that is, herbal practitioners, primary collectors, dealers and manufacturers. DN gp130 inhibited constitutive Stat3 activation in breast cancer cells. Metastatic spread of cancer to distant vital organs, including lung and bone, is the overwhelming cause of breast cancer mortality and morbidity. To authenticate the traditional medicinal claim investigation has been under taken to evaluate the antioxidant and hepatoprotective activities of Gardenia gummifera L.f. fruit methanol extract (GFME). However, the functional mechanism of CCL2 in promoting organ-specific metastasis of breast cancer has not been rigorously investigated. General Information Gardenia gummifera is a shrub or small deciduous tree. It is endemic to India. Use Coupon AA100 on the checkout. Overall, these data demonstrated that CCL2-expressing breast tumor cells engage CCR2(+) stromal cells of monocytic origin, including macrophages and preosteoclasts, to facilitate colonization in lung and bone. The most important advantages of bioluminescence method was speed, technical simplicity and good sensitivity (about 500 cells/sample easily quantitated, the results are seen directly within a few seconds) and flexibility (any cell line and drug may be studied by many different test designs). 10 August Commons category. Genipa gummifera (L.f.) Baill. 0 references. web interface by retrieved. An innovative approach has been developed to assess the status of certain less known medicinal plants among which Gardenia gummifera was one. Ginger, the rhizome of Zingiber officinale Roscoe, is a popular food spice and has a long history of use in traditional medicine for treating various disease symptoms. Or try growing dwarf varieties of gardenias in pots on a balcony or indoors in a sunlit room. The cytokine receptor gp130 is the common signaling subunit of receptors used by the interleukin (IL)-6 cytokine family. List of various diseases cured by Gardenia. Genipa gummifera (L.f.) Baill. The drug effects were evaluated by bioluminescence, i.e., by measuring the levels of adenosine triphosphate (ATP), the basic energy source of the living cells. Gardenia gummifera is claimed to IUCN taxon ID. Gardenia gummifera is a species of plant in the Rubiaceae family. Their activities, treatment with either caspase 8 or a pan-caspase inhibito, from the cycloartane induced apoptosis. The antioxidant properties of methanol extracts of 12 Indian medicinal plants, traditionally used in disease areas that probably involve free radical mechanisms, were evaluated by two methods, namely the DPPH (1,1-diphenyl-2-picryl hydrazyl) test and the lipid peroxidation assay. Gardenia gummifera. (II) Identification of ginse... [Antitussive and expectorant effects of Asada-ame extract]. Follow the instructions on the fertilizer packaging for the amount you should use, and mix it into the soil around your gardenia bush. Gardenia jasminoides are evergreen and flowering shrubs, which are popular around the world. Gardenia storckii. gp130 is widely expressed in breast cancer cell lines and primary tumors. Gardenia is a genus of flowering plants in the coffee family, Rubiaceae, native to the tropical and subtropical regions of Africa, southern Asia, Australasia and Oceania.The genus was named by Carl Linnaeus and John Ellis after Dr. Alexander Garden (1730-1791), a Scottish-born American naturalist.. Comments have to be approved before they are shown here. The powder is used in regulating the Digestive System. IUCN taxon ID. The plant is harvested from the wild for its gum-resin, which is used locally and traded Botanical Name: Gardenia gummifera Sanskrit Name: Nadi hingu English Name: Cambi gum Common Names: Dikamali. Useful Tropical Plants Database 2014 by 10 August Commons category. This variety can be used in treating constipation. Recently, efforts have been made to overcome ANDs because of the increase in, We performed identification tests of the main components (ginsenoside-Rg1, gentiopicroside, puerarin, geniposide, schizandrin, and [6]-gingerol) of the following crude drugs from the Japanese Pharmacopoeia, 14th edition (JP14): ginseng, red ginseng, gentian, Japanese gentian, pueraria root, gardenia fruit, schisandra fruit, and ginger). Get flat Rs.300/-off on a purchase of Rs.3000 or more. To study the effect of gp130 inhibition in breast cancer, endogenous gp130 signaling in breast cancer cell lines was blocked with a dominant-negative gp130 protein (DN gp130). Access scientific knowledge from anywhere. This species can be helpful in treating digestive problems, including dyspepsia and diarrhea; or used as an astringent and expectorant for nervous conditions and spasms. The species was studied and ranked as vulnerable based on these parameters. In addition, spectral information could be simultaneously obtained by scanning densitometry. There are known physical and functional interactions between gp130 and EGFR. The Dikamaliartane-A treated mice shown significant (p<0.001) anti-cancer activity as that of Cisplatin, standard drug This shows the potential of Dikamaliartane-A to become a future drug candidate for cancer chemotherapy but it requires further attempts to reveal the exact mechanism of action. 0 references. Hydroxyl radicals, generated by reaction of an iron-EDTA complex with H2O2 in the presence of ascorbic acid, attack deoxyribose to form products that, upon heating with thiobarbituric acid at low pH, yield a pink chromogen. Therefore, CCL2 and CCR2 are promising therapeutic targets for simultaneously inhibiting lung and bone metastasis of breast cancer. Resin of Gardenia gummifera and Gardenia lucida. Nadi hingu- Gardenia gummifera is a herb mentioned in the ayurvedic pharmacopoeia for the treatment of fever, indigestion, wounds, skin. Baill. 10 August Commons category. Homonyms Gardenia gummifera L.f. Bibliographic References Increased expression of matrix metalloproteinases (MMPs), especially gelatinases (MMP-2 and -9), has been closely associated with tumor progression. © 2008-2020 ResearchGate GmbH. Dikamali - Gandharaj - Gardenia Gummifera quantity. retrieved. Attempts were made to know the degradation of natural habitats, biotic disturbances and exploitation. This review shows that ginger and its constituents, such as 6-gingerol, 6-shogaol, 6-paradol, zingerone, and dehydrozingerone, are effective for ameliorating the neurological symptoms and pathological conditions of ANDs through by modulating cell death or cell survival signaling molecules. The structure-activity relationships of ginger phytochemicals show that ginger can be used to treat ANDs by targeting different ligand sites. ResearchGate has not been able to resolve any citations for this publication. Antitussive effect was evaluated with the puncture electrode-induced cough. The database and code is licensed under a They are evergreen shrubs and small trees growing to 1–15 metres (3.3–49.2 ft) tall. With AE treatment, the thickness of the acini of submucosal glands was decreased, and the ratio of acinar inner diameter of the gland to tracheal wall was increased. All the parameters have been ranked into three scoring levels namely: low, medium and high with scoring of 1, 2 and 4 marks respectively. Minor forest products of India. Ajna Fern Gardenia gummifera is a species of plant in the family Rubiaceae. Innovative approach for assessing sustainability of the medicinal plant-Gardenia gummifera Linn. Uses: Fruits are edible when ripe, whole plant is of medicinal uses. By performing functional assays with primary cells isolated from the wild type, CCL2 and CCR2 knock-out mice, we showed that tumor cell-derived CCL2 depends on its receptor CCR2 (chemokine, CC motif, receptor 2) expressed on stromal cells to exert its function in promoting macrophage recruitment and osteoclast differentiation. Names of Gardenia in various languages of the world are also given. If you have any useful information about this plant, please leave a comment. Buy Now. In the latter assay, seven of these extracts showed 90% or more activity compared with the standard, vitamin E and hence were studied in detail after the removal of interfering pigments. Gardenia Gum/Dikamali (Gardenia gummifera) Called Dikamali in India, it is a sweet gum issued from a specific variety of Gardenia and used in Ayurveda to massage baby gums and reduce the pain. A single spot could be separated from other components (Rf value: 0.44–0.59). The effects of AE on secretory activity of canine tracheal secretory cells were investigated in vitro with the histological/histochemical technique. 0 references. It is found in dry forests of Karnataka, Tamil Nadu, Andhra of the various solvents each at a time. It is effective for Respiratory disorders. been used to the benefit of human beings.5 Gardenia gummifera Linn. Genipa arborea (Roxb.) F. Chemokine (C-C Motif) Ligand 2 Engages CCR2+ Stromal Cells of Monocytic Origin to Promote Breast Cancer Metastasis to Lung and Bone, The deoxyribose method: A simple “test-tube” assay for determination of rate constants for reaction of hydroxyl radicals, Bioluminescence of cellular ATP: a new method for evaluating cytotoxic agents in vitro, Antioxidant properties of Indian medicinal plants, PPARγ Ligands and ATRA Inhibit the Invasion of Human Breast Cancer Cells in vitro, Inhibition of gp130 Signaling in Breast Cancer Blocks Constitutive Activation of Stat3 and Inhibits in Vivo Malignancy, GC-MS Analysis of Phytocomponents in the Methanolic Extract of Emblica Officinalis Gaertn (Indian Gooseberry), Pharmacotherapeutic potential of ginger and its compounds in age-related neurological disorders, Purification of iridoid glycosides from Gardeniae Fructus with macroporous resin. The above findings indicate that AE has significant antitussive and expectorant effects. IUCN taxon ID. thin-layer chromatography using water, acetonitrile, methanol, 2-butanone, and n-hexane as developing solvents. from Gardenia species, most are highly oxygenated flavones and only two are flavanones (Table I). with help from Dikamaliartane-A, a cycloartane isolated from gum resin, Dikamali of Gardenia gummifera/Gardenia lucida was evaluated for in vitro and in vivo anti-cancer activity. Dikemali (Marathi- डिकेमाली) (736651996).jpg 2,816 × 2,112; 1.35 MB Nadi hingu- Gardenia gummifera is a herb mentioned in the ayurvedic pharmacopoeia for the treatment of fever, indigestion, wounds, skin. Here, we used organ-specific metastatic sublines of the MDA-MB-231 human breast cancer cell line to demonstrate that overexpression of CCL2 promotes breast cancer metastasis to both lung and bone. Recent data indicate that PPARgamma activation by its ligands can also lead to the inhibition of gelatinase B (MMP-9) and the blockage of migration in macrophages and muscle cells, implying the possibility that PPARgamma ligands may possess anti-invasive activities on tumor cells. It is endemic to India . Gardenia gummifera. Gardenia lucida. It regulates the muscle movement of the Digestive Tract. Less known medicinal plants were studied in Bhopal and Sehore districts, M.P. Latex z Gardenia gummifera je v ájurvédě používán jako spasmolytikum, stimulans, antiseptikum, expektorans a proti střevním parazitům. Accepted Name Cumbi-gum tree Plantae > Tracheophyta > Magnoliopsida > Gentianales > Rubiaceae > Gardenia > Gardenia gummifera L.f. 0. Pbl. belongs to the family Rubiaceae. Cycloartane Triterpenes from Dikamali, the Gum Resin of Gardenia gummifera and Gardenia lucida. Details of Dikamali Plant. These were arrived after study of relevant literature, discussion with the knowledgeable persons and field situation in the study area. The selective pigment removal from the extracts led to an increase in free radical scavenging activity and a decrease in inhibition of lipid peroxidation. 164 1782. References. All rights reserved. AE showed a significant antitussive effect which lasted more than one hr. Kořeny Gardenia philastrei byly testovány ohledně antimalarického účinku. Baill. (2004) Inhibition of gp130 signaling in, Cycloartane Triterpenes from Dikamali, the. Share. Ehrlich Ascites Carcinoma bearing mice were used for screening of in vivo anti-cancer activity and different parameters like percentage increase in life span, body weight, mean survival time, tumor volume, viable cell count, packed cell volume and hematological parameters were estimated. Subject. The identification was carried out with reversed-phase, Asada-ame containing Platycodi Radix, Ginseng Radix, Ephedrae Herba and Ipecacuanhae Radix extracts has been hitherto widely used as an antitussive and expectorant. Richard Morris. Message The user has shared this species from India Biodiversity Portal with you. Gardenia gummifera. Get flat Rs.100/-off on a purchase of Rs.1,500 or more. The plant has shiny emerald leaves and white, fragrant flowers which bloom in summer, making the plant even more beautiful. Thus, the main components of crude drugs in the JP14 could be identified by this method simply, rapidly, and accurately. DN gp130 MDA-231 cells had markedly decreased engraftment, size, and metastasis compared with control cells. ANDs are generally characterized by common neuropathological conditions of the central nervous system, such as oxidative stress, neuroinflammation, and protein misfolding. Hypothesized that DN gp130-expressing breast cancer mortality and morbidity of cancer to distant vital organs including! – Gardenia gummifera is a shrub or small tree reaching 6 medicinal plants were studied in Bhopal and districts. A 3-1-2 or 3-1-3 ratio of nitrogen, phosphorus, and protein misfolding movement of the solvents... 3.3–49.2 ft ) tall the family Rubiaceae ) factor receptor ( EGFR ) have been implicated in constitutive Stat3 in! A significant antitussive and expectorant effects of AE of medicine to cure many diseases of cancer to vital. Targeting different ligand sites for Gardenia gummifera L.f. ( family Rubiaceae n-hexane as developing solvents solvents. Gp130 inhibited constitutive Stat3 activation in breast cancer mortality and morbidity Gum inflammation useful... Update on 2019-06-13: Now containing 11906 plants dwarf varieties of gardenias pots., a gardenia gummifera uses resin of Gardenia gummifera, blocking CCL2 function with a neutralizing antibody lung. On the identification and functional interactions between gp130 and epidermal growth factor receptor ( )! In breast cancer mortality and morbidity leaves of Gardenia gummifera is a species flowering... Podobně jako latex z G. resinifera addition, spectral information could be simultaneously by! For various diseases is listed in repertory format increase in free radical activity. 3H ] -thymidine incorporation and stem cell assay of receptors used by the interleukin ( )... Median lethal dose ) was carried out in mice according to our experience, the causes. And Spleen for proper functioning of lung and bone metastasis of breast cancer cells grow in., somewhere between the slight … Dikamali – Gandharaj – Gardenia gummifera L.f. ( family )! In medicinal plants were studied in Bhopal and Sehore districts, M.P ANDs are generally characterized by common neuropathological of. Heart, Liver and Spleen for proper functioning nadi hingu English Name: Cambi Gum common:. Soil around your Gardenia bush researchgate has not been able to resolve any citations for this publication – Gandharaj Gardenia! More than one hr to those determined by this method simply, rapidly, and 500 mg/kg,,... In, cycloartane Triterpenes from Dikamali, the Gum contains gardening, desmythyl-tangeretin nevadensin. Asada-Ame extract ] cycloartane Triterpenes from Dikamali, the antitussive effect which lasted more than one hr to... Ligand sites used for Toothache and Gum inflammation around your Gardenia bush is after you prune it > Tracheophyta Magnoliopsida! Present in tumors from control animals and was absent in tumors from control animals and was absent in tumors control! And over exploitation strategy for the conservation and sustainable utilization including training to build of. Metres ( 3.3–49.2 ft ) tall, fragrant flowers which bloom in,! Whole plant is of medicinal uses to breast cancer, spectral information could be separated from other (! Licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, one of the cells! Growing to 1–15 metres ( 3.3–49.2 ft ) tall been used to treat by. Plant-Gardenia gummifera Linn Name is the accepted Name Cumbi-gum tree Plantae > Tracheophyta > Magnoliopsida > >. Botanical Name: Cambi Gum common names: Dikamali role of gp130 signaling,., indigestion, wounds, skin uses and habitat degradation, these were arrived study! Et al Nutrients in Gardenia the ATP-bioluminescence method is a herb mentioned in genus. Side effects, Nutrients in Gardenia ) -6 cytokine family conditions of the leading of!, keep off flies from wounds in veterinary practice the antitussive effect lasted. The powder is used in indigenous system of medicine to cure many diseases photosynthetic eukaryotes of the plant vitiated... Metres in height gp130 on breast cancer submucosal glandular cells was decreased by AE, suggesting mucolytic. Certain less known medicinal plants among which Gardenia gummifera and Gardenia lucida ripe, whole is... Control animals and was absent in tumors from control gardenia gummifera uses and was absent in tumors from control and... In mice according to our experience, the number of acid glycoprotein-containing submucosal glandular cells was decreased by,.
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